Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective

Dissolution Testing for Poorly Soluble Drugs: A Continuing Perspective

The development of a meaningful dissolution procedure for drug products with limited water solubility has been a challenge to both the pharmaceutical industry and the agencies that regulate them. These challenges include developing and validating the test methods, ensuring that methods are appropriately discriminatory, and addressing the potential for an in vivo–in vitro correlation (IVIVC). Di...

A New Crystal Engineering Technique for Dissolution Enhancement of Poorly Soluble Drugs Combining Quasi-emulsion and Crystallo-co Agglomeration Methods

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

A New Crystal Engineering Technique for Dissolution Enhancement of Poorly Soluble Drugs Combining Quasi-emulsion and Crystallo-co Agglomeration Methods

A target of best dissolution improvement of poorly soluble drugs is a necessity for the success of formulation in industry. The present work describes the preparation, optimization, and evaluation of a new spherical agglomeration technique for glimepiride as a model of poorly soluble drugs. It involved the emulsification of a drug solution containing a dispersed carrier that tailors the crystal...

Acceptable Analytical Practices for Dissolution Testing of Poorly Soluble Compounds

56 Pharmaceutical Technology DECEMBER 2004 Cynthia K. Brown is the head of analytical development in pharmaceutical product research and development at Eli Lilly and Company. Hitesh P. Chokshi, PhD, is a research director in pharmaceutical and analytical R&D at Hoffmann-La Roche Inc. Beverly Nickerson, PhD, is an associate research fellow in analytical research and development at Pfizer Inc., E...

Dissolution: a Continuing Perspective